Day 1 :
Spanish National Research Council, Spain
Time : 09:30-09:55
Nekane Guarrotxena was a PhD in chemistry from the University of Complutense, Madrid-Spain (1994). She held post-doctoral research positions at ENSAM, Paris-France (1994-1995) and University of Montpellier-France (1995-1997). She was the Vice-Director of ICTP-CSIC (2001-2005) and visiting-professor at UCSB and at UCI, California-USA (2008-2011). She is currently Research Scientist at the ICTP-CSIC-Spain. She has published more than 60 peer-reviewed publications, 4 books (also co-editor), more than 24 book chapters and 1 patent; and serves as an Editorial Board member of several journals, organizing committee member of scientific-technological events and External Expertise Consultant on I+D+i for National and International Agencies. Her studies focuse on the synthesis and assembly of hybrid-nanomaterials, nanoplasmonics, smart nanomaterials and their nanobiotechnology applications (bioimaging, drug delivery, therapy and biosensing).
Single-molecule sensitivity of SERS has brought to prominence the special role played by so called SERS hotspots. Given that nanometer-scale junctions between nanoparticles produce significant electric field enhancement, the use of SERS-active dimers provides a suitable platform for developing effective sensing, imaging and therapy methodologies. Moreover, the relevant implementation of SERS active species design has opened new pathways and strategies for the SERS application in the clinical and medical field. Herein, I will present how encoded SERS metal NPs result promising multifunctional nanomaterials for biomedical applications. Particularly, SERS tag-synthesis, assembly and optical features will be stated and several examples of their use in detection, imaging, drug loading and therapy will be provided in order to show the remarkable and potential applicability in nanomedicine on the basis of their unique physicochemical features, sensitivity, selectivity and multiplexing capabilities.
Helmholtz-Zentrum Geesthacht, Germany
Time : 09:55-10:20
Karl Ulrich Kainer is the director of the Magnesium Innovation Centre (MagIC) at the Helmholtz Centre Geesthacht. The main focus of the research in MagIC, headed by Prof. Karl Ulrich Kainer, is the development of magnesium-based materials for diverse applications, for example in the transport and medical sectors. Special emphasis is placed on alloy development and on the optimization of existing and new processing technologies. Scientific fundamental research and application-oriented investigations are necessary in order to produce magnesium materials with the optimum spectrum of properties for specific service applications. MagIC has established capabilities and the appropriate equipment for this purpose.
Corrosion behavior of Magnesium and its alloys are normally crucial for numerous applications and hinder often its use. But this disadvantage turns into a tremendous benefit in the area of degradable implants. Here, Magnesium alloys gained interest as biocompatible, degradable implant materials. Magnesium is an essential element for the human body and therefore the body owns a regulating system that balances intake and excretion of Magnesium. Therefore a toxic accumulation can be avoided. Additionally Magnesium alloys are showing better mechanical properties compared to polymers, titanium, stainless steels or cobalt-chromium alloys as their strength and stiffness is much closer to human bone. Besides applications in the musculo-skeletal system they are also suitable as stent materials in the cardiovascular system. And again they offer advantages compared to other stent materials like polymers, stainless steels and titanium. One advantage of Magnesium based implant materials is that it can be resorbed by the human body after a given time. This is of benefit e.g. for stents as well as for implants that are used in children traumatology. In the first case there is still a risk of restenosis which requires now a coronary bypass surgery. In the case of bone implants for children a removal of permanent implants would be necessary in any case due to still growing bone of children. However, the requirements for stents or bone implants are different. To adjust processability as well as properties alloying and process optimization are necessary. We will report the state of the art in the area of rare earth containing Magnesium alloys and the developments at the Magnesium Innovation Centre.
1. N. Hort, Y. Huang, D. Fechner, M. Störmer, C. Blawert, F. Witte, C. Vogt, H. Drücker, R. Willumeit, K. U. Kainer, F. Feyerabend, Magnesium alloys as implant materials - Principles of property design for Mg-RE alloys, Acta Biomaterialia 6 (2010) 1714-1725
2. L. Yang, N. Hort, D. Laipple, D. Höche, Y. Huang, K. U. Kainer, R. Willumeit, F. Feyerabend, Element distribution in the corrosion layer and cytotoxicity of alloy Mg–10Dy during in vitro biodegradation, Acta Biomaterialia 9 (2013) 8475-8487
3. A. Srinivasan, C. Blawert, Y. Huang, C. L. Mendis, K. U. Kainer, N. Hort, Corrosion behaviour of Mg-Gd-Zn- based alloys in aqueous NaCl solution, Journal of Magnesium Alloys 2 (2014) 245-256
4. L.-L. Shi, Y. Huang, L. Yang, F. Feyerabend, C. L. Mendis, R. Willumeit, K. U. Kainer, N. Hort, Mechanical properties and corrosion behavior of Mg−Gd−Ca−Zr alloys for medical applications, Journal of the Mechanical Behavior of Biomedical Materials 47 (2015) 38-48.
5. O. Charyeva, F. Feyerabend, R. Willumeit, D. Zukowski, C. Gasqueres, G. Szakács, N. A. Agha, N. Hort, F. Gensch, F. Cecchinato, R. Jimbo, A. Wennerberg, K. S. Lips, In Vitro Resorption of Magnesium Materials and its Effect on Surface and Surrounding Environment, MOJ Toxicol 2015, 1(1): 00004.
6. M. Vlcek, F. Lukac, H. Kudrnová, B. Smola, I. Stulíková, M. Luczak, G. Szakács, N. Hort, Regine Willumeit-Römer, Microhardness and In Vitro Corrosion of Heat-Treated Mg–Y–Ag Biodegradable Alloy Materials 10 (1) (2017) 55-66
7. L. Yang, L. Ma, Y. Huang, F. Feyerabend, C. Blawert, D. Höche, R. Willumeit-Römer, E. Zhang, K. U. Kainer, N. Hort, Influence of Dy in solid solution on the degradation behaviour of binary Mg-Dy alloys in cell culture medium, Materials Science & Engineering C 75 (2017) 1351–1358.
8. M. Bartosch, H. Peters, A. Koerner, B. Schmitt, F. Berger, N. Hort, F. Witte, New methods for in vivo degradation testing of future stent materials, Materials and Corrosion (2017) 1-11.