Materials Science and Engineering

Biography

Biography: Stiliyana Pereva

Abstract

Cyclodextrin (CDs) have a vast and important applications in many fields of natural sciences – chemistry, pharmacy, gas storage, catalysis, foods, cosmetics. This interest and nearly 40 years of research on CDs is due to their structure – they have a hydrophobic cavity and a hydrophilic exterior, thus they can be hosts of molecules with proper size, which can be entrapped into their cavity. Ibuprofen and naproxen are non-steroidal anti-inflammatory drugs with high bioavailability and permeability, but low water solubility.

Very few researches investigate the complex efficiency and how this can improve the solubility of the drugs in water, their properties and also shed a light to the mechanism of complex formation. We propose a modified ball milling method (with the use of a solvent), which is very effective, compared to the classical pharmaceutical methods – it’s cheap, environmentally friendly and can be applied in an industrial scale. With the help of thermal analysis (Differential Scanning Calorimetry and Thermal Gravimetry), we were able for a first time to quantitatively determine how efficient is this modified synthetic method. We proved that for ibuprofen complexes 1 molecule ibuprofen, replaces 7 molecules water from the cavity of the cyclodextrin.

Recent Publications

1. Pereva, S., Himitliiska, T., Spassov, T., Stoyanov, S.D., Arnaudov, L.N., Dudev, T. (2015) Cyclodextrin-Based Solid-Gas Clathrates., Journal of Agricultural and Food Chemistry, 63, Issue 29, Pages 6603-6613.

2. Pereva, S., Sarafska, T., Bogdanova, S., Spassov, T. (2016), Efficiency of "cyclodextrin-ibuprofen" inclusion complex formation., Journal of Drug Delivery Science and Technology, 35, Pages 34-39.

3. Angelova S., Nikolova V., Pereva S., Spassov T., Dudev T. (2017) α-Cyclodextrin: How Effectively Can Its Hydrophobic Cavity Be Hydrated?, J Phys Chem B., (39):9260-9267.