Dmitry Volodkin
Nottingham Trent University, United Kingdom
Title: Two- and three-dimensional multilayer bio-coatings as novel drug delivery systems. From nano to micro
Biography
Biography: Dmitry Volodkin
Abstract
Polymer multilayers first introduced about two decades ago are nowadays widely used towards bio-applications in tissue engineering and regenerative medicine. Our research is focused on active 2D and 3D multilayer structures (e.g. planar films, capsules, beads) with tailor-made properties. Such structures have a fine-tuned architecture, controlled thickness from nano to macro, adjusted softness from Pa to GPa, almost unlimited variety of functional components, and externally activatable drug release. In this talk I present our recent findings in mild and effective immobilization of biomolecules (proteins, nucleic acids, small drugs, etc) and approaches for release/delivery the biomolecules in a controlled manner. The externally triggered release on demand by IR-laser light and cell biology studies including extra- and intra-cellular delivery will be considered. The developed structures offering localized, remote, and non-invasive release of biomolecules are indispensable for applications in tissue engineering, and especially for single cell studies where high precision of delivery in space and time is highly desirable.
Recent Publications
1. Volodkin D & von Klitzing R (2014) Competing mechanisms in polyelectrolyte multilayer formation and swelling: Polycation–polyanion pairing vs. polyelectrolyte–ion pairing. Curr Opin Colloid Interface Sci 19: 25-31.
2. Volodkin D (2014) CaCO3 templated micro-beads and -capsules for bioapplications. Adv Colloid Interface Sci 207: 306-324.
3. Prokopovic VZ, Duschl C & Volodkin D (2015) Hyaluronic Acid/Poly-l-Lysine Multilayers as Reservoirs for Storage and Release of Small Charged Molecules. Macromol Biosci 15: 1357-1363.
4. Vikulina AS, Anissimov YG, Singh P, Prokopovic VZ, Uhlig K, Jaeger MS, von Klitzing R, Duschl C & Volodkin D (2016) Temperature effect on the build-up of exponentially growing polyelectrolyte multilayers. An exponential-to-linear transition point. PCCP 18: 7866-7874.
5. Prokopovic VZ, Vikulina AS, Sustr D, Duschl C & Volodkin DV (2016) Biodegradation resistant multilayers coated with gold nanoparticles. Towards tailor-made artificial extracellular matrix. ACS Applied Materials & Interfaces 8: 24345-24349.