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Orly Dym


Orly Dym

Structural Proteomics Unit, Israel

Biography

She completed her PhD in 1994 from the Weizmann Institute of Science, Israel under the supervision of Prof Joel Sussman and postdoctoral studies from the University of California Los Angeles, under the supervision of Prof David Eisenberg. Since 2003 she is the Crystallographer at the Structural Proteomics Unit (SPU), Weizmann Institute of Science, Israel. For the last 15 years she has been a member of the SPU where she lead the unit of protein crystallography which include protein crystallization, elucidating the three-dimensional (3D) structure of proteins. She had determined the 3D structure of 350 proteins and protein complexes, some related to human disease, and others including engineered non-natural enzymes and non-natural protein complexes. Some has contributed to the development of drugs, while one has directly benefited enzyme replacement therapy for a human disease. In addition, she has carried out detailed structural analysis on many of these structures, which has greatly aided the understanding the correlation between 3D structure, function, selectivity and stability. She has published more than 50 papers in reputed journals, 10 of which as first author

Abstract

Abstract : The impact of crystallization conditions protein constructs and space groups on structure based drug design